BDNF Unveiled: Exploring Its Role in Major Depression Disorder Serotonergic Imbalance and Associated Stress Conditions

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that plays significant role in the survival and development of neurons, being involved several diseases such as Alzheimer’s disease major depression disorder. The association between BDNF depressive disorder subject extensive research. Indeed, numerous studies indicate decreased levels are linked to an increased occurrence symptoms, neuronal loss, cortical atrophy. Moreover, it has been observed antidepressive therapy can help restore levels. In this review, we will focus on serotonergic imbalance associated stress conditions, particularly hypothalamic–pituitary–adrenal (HPA) axis dysregulation oxidative stress. All these features highly connected signaling pathways context disease, exploring topic aim advance our understanding disorder, improve diagnostic treatment approaches, potentially identify new therapeutic targets alleviate heavy burden society.